L1 /
10
CH3041
PAH TOXICITY
• Toxicity: low
acute but
high chronic toxicity.
high chronic toxicity.
• Benzo[a]pyrene BaP is a
carcinogen that requires
bioactivation to form the
active epoxide metabolite
which binds to DNA.
carcinogen that requires
bioactivation to form the
active epoxide metabolite
which binds to DNA.
• PAHs also
interact with the
AHH receptor.
AHH receptor.
•In general the problem
PAHs
are mutagenic, carcinogenic and teratogenic
are mutagenic, carcinogenic and teratogenic
• PAHs are
hydrophobic, lipophilic, volatility is low, they are dense & are quite stable.
BaP : KOW » 6, pvap 10-10, r 1.35, sol. 3.8 mg/ L
BaP : KOW » 6, pvap 10-10, r 1.35, sol. 3.8 mg/ L
