L1 /
4
CH3041
DIOXIN TOXICITY
• TCDD is the most toxic manmade chemical
known LD50 0.6mg / kg for guinea pigs.
Humans LD50 » 30 mg / kg, t½ is 7 years.
known LD50 0.6mg / kg for guinea pigs.
Humans LD50 » 30 mg / kg, t½ is 7 years.
• Toxicity is dependent on the number of chlorines
& their
substitution positions.
TCDD =
2,3,7,8 TEF = 1.0
PCDD =
1,2,3,7,8 = 0.5
HCDD = 1,2,3,4,7,8 = 0.1.
• Numbering in dioxins & PCDFs are closely
related.
related.
(the fused junctions are not
numbered
you just number around the outside)
you just number around the outside)
