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Ukrainian presidential candidate Viktor Yushchenko was poisoned with dioxin, doctors said Saturday, adding that the highly toxic chemical could have been put in the opposition leader's soup, producing the severe disfigurement and partial paralysis of his face

The binding of these transformed heteromeric TCDD:AHH complexes to specific DNA sequences (Dioxin Responsive Elements (DREs)) adjacent to the cytochrome P4501 gene leads to DNA bending, chromatin disruption, increased promoter accessibility and increased rates of transcription initiation of the gene with the subsequent accumulation of cytochrome P450-specific mRNA. The presence of the AHH complex in a wide variety of species and tissues and with its ability to act as a ligand-dependent transactivator of gene expression suggests that many of the toxic and biological effects of PAHs, dioxins etc result from
differential alteration of gene expression in susceptible cells.

Vung Tau harbour – Vietnam. 1980 – 1994 170 navy personnel died from a range of cancers.

The distillation concentrated the dioxins into the drinking water.

In the early 2000s, residents of the city of New Plymouth, New Zealand, report many illnesses of people living around and
working at the Dow Chemical plant. This plant ceased production of 2,4,5-T in 1987.

Indicate the bioaccumulation of PAH residues??

the allowable concentration of air lead is 0.7 µg/m3 in Yugoslavia mean is 25 µg/m3

Blood Pb is 32 µg/dL