‹header›

‹date/time›

Click to edit Master text styles

Second level

Third level

Fourth level

Fifth level

‹footer›

‹#›

Type I pyrethroids affect Na+ channels in nerve membranes (both sensory and motor) and
give long afterpotential similar to DDT.

[Na] high outside cell, [K] high inside cell.
Powers nerve impulse as K ion channel releases pulse of K+.

Powers the entry of glucose into cells – active transport using Na+.

ORL-RAT LD50 87 mg kg-1
ORL-HMN LDLO 500 mg kg-1 lethal dose lowest observed

LD of 200 – 500mg/kg reported for DDT oral dose

Still produced in Italy, India, Indonesia around 2800t/yr

1ppm DDT in human fat – 47 cases analysed in UK 1995 - 1997

Endosulfan still registered and used big time for cotton

Malathion is called Maldison in APVMA listing of registered chemicals.
Contaminants include iso-malathion (storage under extreme conditions) LD50 113 mg/kg
O,S,S-trimethylphosphorodithioate LD50 = 20 mg/kg.

Currently under review 2003.