L1 /
9
CH3041
CARCINOGENESIS
• Mechanism of operation of a
carcinogen
The chemical may: (i) interact with the DNA
in the cell to form a DNA adduct.
in the cell to form a DNA adduct.
or (ii)
interfere with a receptor (eg AHH).
or (iii)
interfere with protein synthesis.
As a
result gene expression is altered.
Gene: a segment
of DNA that carries a base sequence that directs
the synthesis of a particular protein, tRNA, or mRNA
the synthesis of a particular protein, tRNA, or mRNA
