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5
CH3041
KINETICS &
DYNAMCS
• Toxicokinetics : the quantification of the
course of absorption, distribution, bio-transformation and excretion of a toxicant.
The study of the input, output and movement of a toxicant through the body.
course of absorption, distribution, bio-transformation and excretion of a toxicant.
The study of the input, output and movement of a toxicant through the body.
• Toxicodynamics : the study of the toxic
response of the organism involving primary
reaction at the receptor, biochemical response and then observable effects.
response of the organism involving primary
reaction at the receptor, biochemical response and then observable effects.
• Receptor site : a part
of a macromolecule designed to accept a target molecule.
Some toxic effects occur by interaction of
the toxicant with a receptor site.
eg. CO reacts with haemoglobin.
Some toxic effects occur by interaction of
the toxicant with a receptor site.
eg. CO reacts with haemoglobin.
