A. Kinetic Phase:
Uptake and elimination. Determines chemical form and
transport of toxicant to site of action.
Absorption Distribution Metabolism
Elimination
Fields of Study: Pharmacokinetics (drugs) and
Toxicokinetics (all toxics).
B. Dynamic Phase:
Toxicity phase. A response is elicited at the target
site.
toxicant binds to and/or reacts with the target site
suborganismal response elicited drives physiological
and or behavioural responses can be manifested in a
continuum of intensities (no effect -----> death)