CH1012
L1
/
‹#›
L1
/
11
S
N
2 REACTIVITY
The S
N
2 reaction rate is sensitive to steric
hindrance at the reaction centre.
RCH
2
-X
>
R
2
CH-X
>> R
3
CX
1
o
2
o
3
o
Decreasing rate
Increasing steric hindrance
Once we arrive at the
3
o
haloalkanes
the
steric hindrance is so great that the second
mechanism
S
N
1 becomes the preferred
route
.