CH1012
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CYTOCHROME P450
OXIDATION
• Cytochrome P450 is a heme-protein
complex that is produced in the liver.
complex that is produced in the liver.
•This is the major
mechanism for elimination
of foreign chemicals from the body.
of foreign chemicals from the body.
• It works by conversion of the alkyl or
aromatic part of the foreign chemical into
an alcohol which is water soluble and is
excreted in the urine.
aromatic part of the foreign chemical into
an alcohol which is water soluble and is
excreted in the urine.
