CH1012
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11
OH AND NH PROTONS
OH & NH these are very important protons in biological systems and they have several characteristic features:
1) Chemical shift: fn. of solvent  &  conc.
2) Generally don’t couple to Hs on adjacent Cs due to rapid exchange which results from H-bonding
eg. hydroxyl H is rapidly
exchanging \ Ha never
“sees” a constant H on
O \ no coupling