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CH1012
Zn-ANHYDRASE
Carbonic
anhydrase
- enzyme
catalyst
CO2(g) + H2O(l) H2CO3(aq) D HCO3-(aq)
®
¬
Respiration:
Zn2+ a Lewis
acid activates
H2O so that
it can attack
CO2 in the
active site of
the enzyme.
acid activates
H2O so that
it can attack
CO2 in the
active site of
the enzyme.
• 70% of CO2 ends up
transferred to lungs
as HCO3-, hemoglobin 20% See BLB: P270
as HCO3-, hemoglobin 20% See BLB: P270
histidines
