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10
CH1012
REACTIONS
Reactions
of Carboxylic Acid Derivatives
1. Base promoted Hydrolysis (Saponification)
This is a nucleophilic acyl
substitution,
a typical reaction of carboxylic acids and
their derivatives.
a typical reaction of carboxylic acids and
their derivatives.
• The Fischer
esterification is an example of
a nucleophilic acyl substitution. There are
two main steps : 1) nucleophilic addition &
2) elimination of the group which has been
substituted (a leaving group).
a nucleophilic acyl substitution. There are
two main steps : 1) nucleophilic addition &
2) elimination of the group which has been
substituted (a leaving group).
