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CH1012
NUCLEOPHILIC ACYL SUBSN.
1. Esters

Nucleophilic acyl substitution
= nucleo. addition + elimination
2. Amides
  test for
 1o amide
R.D.S.          Tetrahedral
                     intermediate
In the amide reaction the tetrahedral intermediate amine centre pulls a H+ off H2O regenerating -OH