L1 /   
12
CH1012
BIOLOGICAL RELEVANCE
Methylation of a neurotransmitter hormone
SAM (S-adenosylmethionine) has a good leaving group (a sulphonium ion).
Adrenaline
      (adrenal gland)
Noradrenaline
SAM
A typical SN2 reaction !
sulfonium compound, is a positively charged sulfur atom carrying three alkyl groups as substituents
Adrenaline and noradrenaline are found in the adrenal gland and in neurons of the peripheral (autonomic) and central nervous systems. maintain internal body state (‘homeostasis’) but, in the brain, they are thought also to influence arousal and mood.
noradrenaline regulates alertness and the sleep-wakefulness cycle