L1 /
8
CH1012
LEAVING GROUPS
The leaving group characteristics are also
important in determining if a reaction will
occur or not as the group must develop
a partial negative charge in the TS for both SN1 & SN2 reactions.
important in determining if a reaction will
occur or not as the group must develop
a partial negative charge in the TS for both SN1 & SN2 reactions.
reactivity
as a function of leaving group
high low
high low
I- > Br- > Cl- >> F- > CH3COO- > OH- > CH3O- > NH2-
stability of anion
In this series F- through to NH2- rarely work
as leaving groups.
as leaving groups.
