• The Greek
physician
Hippocrates wrote in the
5th C BC about a
bitter
powder extracted from
willow bark that could
ease aches &
fevers.
• The active extract of the bark,
called salicin, was
isolated in 1828.
• Salicylic acid
(the actual cmpd
that is
active in salicin) was
esterified
to form Aspirin in 1897.