L1 /
6
CH1012
CYTOCHROME P450 OXIDATION
• Cytochrome P450
is a heme-protein
complex that is produced in the liver.
complex that is produced in the liver.
•This is the major mechanism for elimination
of foreign chemicals from the body.
of foreign chemicals from the body.
• It works by
conversion of the alkyl or
aromatic part of the foreign chemical into
an alcohol which is water soluble and is
excreted in the urine.
aromatic part of the foreign chemical into
an alcohol which is water soluble and is
excreted in the urine.
